![]() The combination of large imaging area, high-plex RNA quantification, and protein imaging offers a unique and powerful tool to explore complex tissues with an unprecedented level of detail. ![]() Visualizing changes in the relative abundance of defined cell types and the relationship between these pathological gene-expression levels and the presence of disease-related proteins demonstrate the ability of the Rebus Esper spatial omics platform to yield high-throughput spatial omics data with single cell resolution. Using these 30 genes and two proteins of interest, the anatomical structures, major neuronal and glial cell types, and changes in disease-related genes could be visualized and analyzed. Hence, tools for engineering microbial robustness are. Use of metabolic inhibitors to elucidate mechanisms of recovery from desiccation stress in the resurrection plant Xerophyta humilis 143 Accesses 48 Citations. Pesticides are widely used in agriculture and household applications around the world. The Rebus Esperâ„¢ automated high-throughput spatial omics platform validated the expression of 30 target genes at the single-cell level in the hippocampus of two disease models plus a wild-type control mouse. Robustness is an important phenotype for bioenergy microbes to acquire but is difficult to engineer. Here we present a methodology which allows accurate gene expression quantification without compromising spatial resolution. Single-cell RNA sequencing provides a powerful approach to study these variables, at the expense however of critical anatomical and morphological information. As biologists pay increasing attention to disordered signaling in diseased cells, to develop new modeling methods and tools for conducting new computational studies is important.Cell-type composition and expression of immune response genes are two key variables in neurodegeneration mouse model studies. These examples support that reconstructed spatiotemporal distributions of key signaling events help elucidate growth control mechanisms. The other two examples illustrate the building of three-dimensional and large-scale models. The Drosophila wing model includes Wnt, PCP, and Hippo pathways and mechanical force, incorporates well-confirmed experimental findings, and generates novel results. To better elucidate the brain mechanisms underlying cognitive, affective, and social processes, NIMH will support research that employs the following Strategies: Strategy 1.1. ![]() We propose it is desirable to explicitly simulate events and orders of gene regulation and protein interactions, which better elucidate control mechanisms, and report a method and tool with three examples. City University of New York ProQuest Dissertations. ![]() Currently computational systems biology aims to infer the control mechanisms by investigating quantitative changes of gene expression and protein concentrations, but this inference is difficult in nature. Elucidating Mechanisms of Biofluorescence and Bioluminescence in Marine Organisms. Signaling pathways important for growth control have been identified, but to identify the mechanisms their transient and context-dependent interactions encode is more difficult. Purpose : We aim to determine how neuroretinal differentiation and ciliary margin specification are coordinated by homeodomain transcription factors Six3. A fundamental biological question is how diverse and complex signaling and patterning is controlled correctly to generate distinct tissues, organs, and body plans, but incorrectly in diseased cells and tissues.
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